Also known as
Clomiphene Citrate
Clomiphene citrate is a non-steroidal selective estrogen receptor modulator. It is sold at PoseidonRX in multiple Magnus-branded course packages and as a standalone 50 mg tablet. The compound acts on the hypothalamic-pituitary axis to restore endogenous testosterone production after exogenous estrogenic or androgenic agents have suppressed it.
Users taking any of these products should verify their specific cycle history, as clomiphene is indicated only when a prior suppression of the HPG axis is present. It is not an anabolic agent and has no direct effect on lean mass accretion in its own right.
Mechanism of Action
Clomiphene citrate binds to estrogen receptors in the hypothalamus, blocking negative feedback from circulating estradiol. This removes the inhibitory signal on GnRH release, which in turn drives an increase in luteinising hormone and follicle-stimulating hormone secretion. The resulting stimulation of Leydig cells restores testosterone synthesis to normal physiological levels.
It does not possess intrinsic androgenic or oestrogenic activity at therapeutic doses. Its entire clinical relevance is therefore tied to its capacity to reverse the hormonal suppression caused by prior anabolic-steroid or other exogenous hormone exposure.
Clinical Indication
Clomiphene is indicated for the management of secondary hypogonadism in men following a course that has suppressed the hypothalamic-pituitary-gonadal axis. It is not used as an adjunct to ongoing anabolic-steroid therapy, nor as a primary anti-estrogen during active cycles.
The standard post-cycle protocol is 50 mg once daily for four weeks. Athletes who have completed a long or high-dose course should ensure their endocrine function has fully normalised before resuming any further exogenous androgen exposure. No other hormonal agent requires concurrent administration unless specifically indicated by the treating physician.
Questions & answers
Is clomiphene an anabolic steroid?
No. It is a non-steroidal selective estrogen receptor modulator with no direct androgenic or oestrogenic activity at therapeutic doses.
What is the standard post-cycle dose of clomiphene?
50 mg once daily for four weeks. This is the only dosing schedule used in the standard protocol and no other hormonal agent requires concurrent administration.
Can clomiphene be taken during an active cycle?
No. It is not indicated as a primary anti-estrogen during active cycles or as an adjunct to ongoing anabolic-steroid therapy.