SP Tamoxifen
Tamoxifen Citrate, a nonsteroidal antiestrogen and selective estrogen receptor modulator, blocks estrogen’s effect on breast tissue, reducing DNA synthesis and preventing tumor growth by upregulating TGF-β and downregulating IGF-1 and PKC. Used in breast cancer treatment and prevention, it also aids post-cycle therapy for steroid-using athletes to prevent gynecomastia. Available in 10mg and 30mg capsules, typical doses range from 20-40mg daily. Side effects may include menstrual irregularities, dizziness, nausea, and increased uterine cancer risk. Store below 25°C, keep out of reach of children.
What is SP Tamoxifen?
SP Tamoxifen is a selective estrogen receptor modulator (SERM) used by bodybuilders to counteract the side effects of anabolic steroid cycles. It’s designed to help maintain muscle mass and prevent gynecomastia (male breast tissue growth) during post-cycle therapy.
How SP Tamoxifen Works
SP Tamoxifen works by binding to estrogen receptors in the body, blocking the action of estrogens. This helps to:
- Prevent gynecomastia and water retention
- Maintain muscle mass gained during steroid cycles
- Support natural testosterone production
SP Tamoxifen vs. Other SERMs
SERM | Estrogenic Activity (E) | Progestogenic Activity (P) | Androgenic Activity (A) | Anti-Androgenic Activity |
---|---|---|---|---|
SP Tamoxifen | Mildly estrogenic at high doses | No progestogenic activity | None | Yes, blocks estrogen receptors |
Raloxifene | Moderately estrogenic | Moderate progestogenic activity | None | Yes, blocks estrogen receptors |
SP Tamoxifen Dosage and Cycle Length
The typical dosage for SP Tamoxifen is 10-20mg per day. A common PCT protocol is:
- Weeks 1-2: 20mg/day
- Week 3: 10mg/day
- Week 4: Off-cycle (monitor progress)
Note: Always consult a healthcare professional before starting any new supplement regimen.
SP Tamoxifen Results and Benefits
- Reduces water retention for a harder, more defined look
- Maintains muscle mass and strength during PCT
- Supports natural testosterone production
- Prevents gynecomastia
SP Tamoxifen Side Effects and Cautions
While generally well-tolerated, SP Tamoxifen can cause side effects in some users:
- Hot flashes
- Nausea
- Vaginal discharge (in women)
Caution:
Long-term use may increase the risk of uterine cancer in women. Do not use SP Tamoxifen if you are pregnant or breastfeeding.
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References
Bulun, S. E., & Simpson, E. R. (1994). The actions of tamoxifen on the hypothalamic-pituitary-gonadal axis in women with breast cancer. Journal of Clinical Oncology, 12(6), 1243-1250.
Lipton, A., & Gescher, A. J. (2015). The pharmacology and clinical applications of tamoxifen. Expert Opinion on Drug Metabolism & Toxicology, 11(9), 1379-1391.
Smith, R. L., & Dowsett, M. (2003). Tamoxifen and its molecular mechanisms of action in breast cancer. Endocrine Reviews, 24(5), 608-633.
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