L-Carnitine BP
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L-Carnitine BP: Essential for fat metabolism, our L-Carnitine supplement aids weight management and enhances exercise performance. Take 2 capsules daily with meals and water. Suitable for adults over 18, consult doctor if pregnant, breastfeeding or under medication. Store below 25°C, avoid light. Not intended to diagnose or treat diseases.
Hello, sports enthusiasts and bodybuilders! Today, we’re going to delve into an essential supplement that’s often overlooked but can significantly impact your performance and overall health – L-carnitine. Specifically, we’ll focus on how it influences blood pressure (BP) regulation, a critical aspect of any athlete’s or bodybuilder’s regimen.
What is L-Carnitine?
L-carnitine, scientifically known as L-3-carboxy-2-hydroxypropyltrimethylazanium, is a naturally occurring amino acid derivative that plays a vital role in energy metabolism. It’s primarily synthesized in the liver and kidneys from the essential amino acids lysine and methionine, with small amounts obtained from dietary sources like red meat, poultry, fish, and dairy products 1.
L-Carnitine and Blood Pressure Regulation
Now, you might be wondering how L-carnitine affects blood pressure. Let’s explore this fascinating relationship.
1. L-Carnitine and Endothelial Function
The endothelium is the inner lining of our blood vessels, responsible for maintaining vascular tone and regulating blood flow. L-carnitine has been shown to improve endothelial function by increasing nitric oxide (NO) production, a potent vasodilator that relaxes blood vessels and reduces peripheral vascular resistance 2.
2. L-Carnitine and Oxidative Stress
Oxidative stress contributes to hypertension by damaging blood vessel walls and promoting inflammation. L-carnitine acts as an antioxidant, protecting cells from oxidative damage and reducing inflammation. This, in turn, helps maintain healthy blood vessels and regulate blood pressure 3.
3. L-Carnitine and Insulin Sensitivity
Insulin resistance is linked to hypertension due to its effect on sodium reabsorption and sympathetic nervous system activity. L-carnitine improves insulin sensitivity by enhancing glucose uptake and utilization in skeletal muscle, indirectly helping regulate blood pressure 4.
L-Carnitine BP Studies: What the Research Says
Several studies have investigated the effects of L-carnitine supplementation on blood pressure. Let’s look at some key findings:
- A systematic review and dose-response meta-analysis found that L-carnitine supplementation significantly reduced systolic blood pressure (SBP) in adults, with a more pronounced effect in hypertensive individuals 5.
- Another study demonstrated that L-carnitine supplementation improved flow-mediated dilation (FMD), a marker of endothelial function, and reduced blood pressure in overweight/obese adults 6.
| Study | Participants | Duration | Dose | Effect on BP |
|---|---|---|---|---|
| Zhang et al. (2019) 7 | Adults (n=1746) | 3-24 months | Varies | SBP reduction: -2.8 mmHg (-4.3, -1.2) |
| Kim et al. (2018) 8 | Overweight/Obese adults (n=55) | 12 weeks | 2g/day | SBP reduction: -5.7 mmHg (-9.4, -2.0) DBP reduction: -3.4 mmHg (-5.5, -1.2) |
L-Carnitine Forms: Which is Best for BP Regulation?
Different forms of L-carnitine are available on the market, each with slightly varying properties and potential benefits.
- L-Carnitine: The most common form, L-carnitine is well-tolerated and has been shown to improve various health markers, including blood pressure.
- Acetyl-L-Carnitine (ALCAR): A popular form of L-carnitine, ALCAR may offer additional cognitive benefits due to its ability to cross the blood-brain barrier. However, its effects on blood pressure are less studied compared to L-carnitine 9.
- Propionyl-L-Carnitine (PLC): PLC has been shown to improve endothelial function and reduce inflammation, which may contribute to better blood pressure regulation 10.
L-Carnitine Dosage for Blood Pressure Regulation
Most studies on L-carnitine and blood pressure used dosages ranging from 500mg to 3g per day. The optimal dose may vary depending on individual factors such as age, health status, and response to supplementation. It’s essential to consult with a healthcare professional before starting any new supplement regimen.
L-Carnitine Side Effects and Safety
L-carnitine is generally considered safe for most adults when taken orally at appropriate doses. Common side effects include stomach upset, restlessness, and a “fishy” body odor 11. People with thyroid issues, seizure disorders, or those taking blood thinners should consult their healthcare provider before using L-carnitine supplements.
L-Carnitine Supplementation: The Bottom Line
L-carnitine supplementation offers promising benefits for blood pressure regulation in sports and bodybuilding communities. By improving endothelial function, reducing oxidative stress, and enhancing insulin sensitivity, L-carnitine can help maintain healthy blood vessels and manage blood pressure levels.
When selecting an L-carnitine supplement, opt for one with a high purity level and third-party certification to ensure quality and effectiveness. PoseidonRX.com offers a wide range of premium-quality supplements, including various forms of L-carnitine tailored to your specific needs.
Remember, while supplementation can be beneficial, it’s crucial to maintain a balanced diet and regular exercise routine for optimal health and performance outcomes. Consult with a healthcare professional or a registered dietitian to determine the best course of action for your unique situation.
Stay informed, stay healthy, and happy lifting!
References
- Borum W, et al. (2004). “L-carnitine.” In: Coates P, et al., eds. Encyclopedia of Dietary Supplements. https://www.ncbi.nlm.nih.gov/books/NBK9273/↩︎
- Kim JS, et al. (2018). “L-Carnitine Supplementation Improves Flow-Mediated Dilation in Overweight and Obese Adults: A Randomized Controlled Trial.” Nutrients, 10(4), 503. https://doi.org/10.3390/nu10040503↩︎
- Cimino M, et al. (2016). “L-Carnitine Supplementation Reduces Oxidative Stress and Inflammation in Overweight/Obese Adults: A Randomized Controlled Trial.” Oxidative Medicine and Cellular Longevity, 2016, Article ID 3847952. https://doi.org/10.1155/2016/3847952↩︎
- Dubnov G, et al. (2020). “L-Carnitine and Insulin Sensitivity: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.” Nutrients, 12(1), 134. https://doi.org/10.3390/nu12010134↩︎
- Zhang Y, et al. (2019). “Effects of L-carnitine supplementation on blood pressure: A systematic review and meta-analysis.” Journal of Hypertension, 37(8), 1680-1691. https://doi.org/10.1097/HJH.0000000000002459↩︎
- Kim JS, et al. (2018). “L-Carnitine Supplementation Improves Flow-Mediated Dilation in Overweight and Obese Adults: A Randomized Controlled Trial.” Nutrients, 10(4), 503. https://doi.org/10.3390/nu10040503↩︎
- Zhang Y, et al. (2019). “Effects of L-carnitine supplementation on blood pressure: A systematic review and meta-analysis.” Journal of Hypertension, 37(8), 1680-1691. https://doi.org/10.1097/HJH.0000000000002459↩︎
- Kim JS, et al. (2018). “L-Carnitine Supplementation Improves Flow-Mediated Dilation in Overweight and Obese Adults: A Randomized Controlled Trial.” Nutrients, 10(4), 503. https://doi.org/10.3390/nu10040503↩︎
- Giamouzis G, et al. (2018). “Acetyl-L-carnitine supplementation in the elderly.” Journal of Geriatric Cardiology: Open Access, 4(1), 1-9. https://doi.org/10.15406/jgcoa.2018.04.00037↩︎
- Suzuki HJ, et al. (2002). “Propionyl-L-carnitine improves endothelial function in patients with coronary artery disease.” Journal of the American College of Cardiology, 39(5), 863-869. https://doi.org/10.1016/S0735-1097(02)01840-X↩︎
- *WebMD: L-Carnitine Side Effects.” https://www.webmd.com/vitamins-supplements/ingredientmono-946-l-carnitine.aspx?activeingredientid=946↩︎
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